Sometimes Zoloft panic attack medicine can cause an increase in the number or severity of panic attacks. Doctors most often respond to this complaint from patients by saying that the patient did not give the medication enough time to set in properly in their system. Some patients elect to ride it out and some elect to give it up. Some doctors will also tell their Zoloft panic attack patients that the increased anxiousness and panic symptoms are “all in their head”—Get a second opinion.